Iranian Red Crescent Medical Journal

Published by: Kowsar

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Mohammad Gharavi 1 , Alireza Sabzevari 2 , Ehsanolah Ghorbanian 1 , * , Rasoul Sajadi 1 and Mohsen Akhondi 1
Authors Information
1 Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Cardiac Anesthesia Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: March 5, 2014, 16 (3); e16099
  • Published Online: March 5, 2014
  • Article Type: Research Article
  • Received: November 10, 2013
  • Revised: January 29, 2014
  • Accepted: February 16, 2014
  • DOI: 10.5812/ircmj.16099

To Cite: Gharavi M, Sabzevari A, Ghorbanian E, Sajadi R, Akhondi M. et al. Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain, Iran Red Crescent Med J. 2014 ;16(3):e16099. doi: 10.5812/ircmj.16099.

Copyright: Copyright © 0, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Gupta S, Ravalia A, Jonnada HR. Pain on injection with propofol. Anaesthesia. 2001; 56(10): 1016[DOI]
  • 2. Wong WH, Cheong KF. Role of tramadol in reducing pain on propofol injection. Singapore Med J. 2001; 42(5): 193-5[PubMed]
  • 3. Morton NS, Johnston G, White M, Marsh BJ. Propofol in paediatric anaesthesia. Pediatric Anesthesia. 1992; 2(2): 89-97[DOI]
  • 4. Haugen RD, Vaghadia H, Waters T, Merrick PM. Thiopentone pretreatment for propofol injection pain in ambulatory patients. Can J Anaesth. 1995; 42(12): 1108-12[DOI][PubMed]
  • 5. King SY, Davis FM, Wells JE, Murchison DJ, Pryor PJ. Lidocaine for the prevention of pain due to injection of propofol. Anesth Analg. 1992; 74(2): 246-9[PubMed]
  • 6. Movafegh A. A Comparison of Metoclopramide And Lidocaine For Preventing Pain On Injection Of Propofol. Tehran Univ Med J. 2003; 61(4)
  • 7. Pang WW, Mok MS, Huang S, Hwang MH. The analgesic effect of fentanyl, morphine, meperidine, and lidocaine in the peripheral veins: a comparative study. Anesth Analg. 1998; 86(2): 382-6[PubMed]
  • 8. Iwama H, Nakane M, Ohmori S, Kaneko T, Kato M, Watanabe K, et al. Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol. Br J Anaesth. 1998; 81(6): 963-4[PubMed]
  • 9. Zhao GY, Guo Y, Bao SM, Meng LX, Zhang LH. Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine. J Clin Anesth. 2012; 24(4): 284-8[DOI][PubMed]
  • 10. Sethi N, Jayaraman L, Sethi M, Sharma S, Sood J. Prevention of propofol pain: a comparative study. Middle East Journal of Anesthesiol. 2009; 20(1): 71-4
  • 11. Scott RP, Saunders DA, Norman J. Propofol: clinical strategies for preventing the pain of injection. Anaesthesia. 1988; 43(6): 492-4[PubMed]
  • 12. Walker BJ, Neal JM, Mulroy MF, Humsi JA, Bittner RC, McDonald SB. Lidocaine pretreatment with tourniquet versus lidocaine-propofol admixture for attenuating propofol injection pain: a randomized controlled trial. Reg Anesth Pain Med. 2011; 36(1): 41-5[DOI][PubMed]
  • 13. El-Radaideh KM. [Effect of pretreatment with lidocaine, intravenous paracetamol and lidocaine-fentanyl on propofol injection pain. Comparative study. Rev Bras Anestesiol. 2007; 57(1): 32-8[PubMed]
  • 14. Beyaz SG, T. Fek A , Tokgoz O. The effect of propofol lipuro with and without lidocaine on injection pain in children. Niger J Clin Pract. 2011; 14(1): 60-4[DOI][PubMed]
  • 15. Kaya S, Turhanoglu S, Karaman H, Ozgun S, Basak N. Lidocaine for prevention of propofol injection-induced pain: A prospective, randomized, double-blind, controlled study of the effect of duration of venous occlusion with a tourniquet in adults. Curr Therap Res. 2008; 69(1): 29-35[DOI]
  • 16. Jalota L, Kalira V, George E, Shi YY, Hornuss C, Radke O, et al. Prevention of pain on injection of propofol: systematic review and meta-analysis. BMJ. 2011; 342[DOI][PubMed]
  • 17. Madenoglu H, Yildiz K, Dogru K, Boyaci A. Efficacy of Different Doses of Lidocaine in the Prevention of Pain Due to Propofol Injection: A Randomized, Open-Label Trial in 120 Patients. Curr Ther Res. 2003; 64(5): 310-6[DOI]
  • 18. Picard P, Tramer MR. Prevention of pain on injection with propofol: a quantitative systematic review. Anesth Analg. 2000; 90(4): 963-9[PubMed]
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